BioNotus

Core business

(Clinical Study Design) ---> Bioanalysis ---> Pharmacometrics (PMX) --- > Actionable insights

Legal Representative

Specific areas of activity

What do we do?

1/ Our Bioanalysis expertise for your pharma and biotech needs 
- Quantitative determination of (a) drugs and their metabolites, (b) biomarkers and endogeneous compounds.
- Metabolite identification (MetID)
- Biological and non-biological matrices (e.g. in vitro, wastewater)  
- Custom method development and routine
 
2/ Our Pharmacometrics (PMX) expertise for your pharma and biotech needs 
- Data exploration and visualization (scoping) prior to modeling
- Non-compartmental PK analysis and allometric scaling
- Physiology-based Pharmacokinetics (PBPK) and PBPK-based scaling
- Population Pharmacokinetic/Pharmacodynamic modeling (popPK/PD)
- Dose-finding in special populations (e.g. neonatal, pediatric, geriatric), a.k.a. Model Informed Precision Dosing (MIPD)
- Clinical Study design
- Project management of the PMX parts of drug development 
 

For what type of studies?

Preclinical till late Phase IV
Bioequivalence studies
Toxicokinetic and Pharmacokinetic studies (ADME(T))
Meta-Analysis
Systematic Reviews
Randomized Controlled Trials
Cohort Studies (Prospective Observational Studies)
Case-control Studies
Cross-sectional studies
Case Reports and Series
Animal Research Studies
Test-tube Lab Research

Who are our clients?

CROs
Biotech companies
Pharmaceutical Industry
Academia
University hospitals
IMI
...

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BioEquivalence Data Management Early Clinical Phases Laboratory Late phase IV Medical Writing Pharmacometrics (Modeling&Simulation) Preclinical Regulatory Statistics Other